Preparation of Chitosan Nanoparticles Loaded with Glutathione for Diminishing Tissue Ischemia-Reperfusion Injury
O. V. Rotar1, K. Tenedja2, A. D. Arkhelyuk3, V. I. Rotar4, I. S. Davidencko5, V. I. Fediv6
1Asst. Prof. O.V. Rotar, General Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine.
2Dr. K. Taneja, Fortis Memorial Research Institute, Gurgaon, India.
3Asst. Prof. O.D. Archelyuck, Department of Correlation Optics, Chernivtsi National University, Chernivtsi, Ukraine.
4V. I. Rotar, General Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine.
5I. S. Davidencko, General Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine.
6V. I. Fediv, General Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine.
Manuscript received on May 10, 2014. | Revised Manuscript Received on May 12, 2014. | Manuscript published on May 18, 2014. | PP:19-23 | Volume-1, Issue-6, May 2014.
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Nanoparticles composed of chitosan or chitosan plus cyclodextrin-beta comlex for tissue delivery of the glutathione were prepared. Mean size of nanoparticle systems were 100-150 nm in both groups. Encapsulation efficiency for glutathione of chitosan/cyclodextrin nanoparticles was 2,5 time higher than simple chitosan system thus leaded to improvement delivery of glutathione to mucosal layer of small intestine and diminishing tissue ischemia-reperfusion injury
Keywords: glutathione, nanoparticles, chitosan, cyclodextrin.